STYK1; NOK; Tyrosine-protein kinase STYK1; Novel oncogene with kinase domain; Protein PK-unique; Serine/threonine/tyrosine kinase 1
Key Feature
Clonality
Polyclonal
Isotype
Ig
Host Species
Rabbit
Tested Applications
WB
WB:1:250~500
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Gene Synonyms
NOK
Alternative Names
STYK1 NOK Tyrosine-protein kinase STYK1 Novel oncogene with kinase domain Protein PK-unique Serine/threonine/tyrosine kinase 1
Molecular Weight(MW)
47577 Da
Function
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity)
Tissue Specificity
Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers
Cellular Localization
Membrane; Single-pass membrane protein (Potential)
The anti- STYK1 Pab is used in Western blot to detect STYK1 in 293 , CEM (center), and mouse kidney cell line/tissue lysates.
Application Notes
WB:1:250~500
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.