Application
Western blot analysis of TESC Antibody (C-term) in mouse cerebellum tissue lysates (35ug/lane).TESC (arrow) was detected using the purified Pab.Application
TESC Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TESC Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.Application
TESC Antibody (C-term) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | TESC Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TESC; CHP3; Calcineurin B homologous protein 3; Tescalcin |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHCFC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CHP3 |
|---|---|
| Alternative Names | TESC CHP3 Calcineurin B homologous protein 3 Tescalcin |
| Molecular Weight(MW) | 24750 Da |
| Function | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin |
| Tissue Specificity | Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta |
| Cellular Localization | Nucleus. Cytoplasm. Membrane (By similarity). Cell membrane. Cell projection, lamellipodium (By similarity). Cell projection, ruffle membrane (By similarity) Note=Colocalizes with SLC9A1 at the plasma membrane |
| Entrez Gene | 54997 |
|---|
Application
Western blot analysis of TESC Antibody (C-term) in mouse cerebellum tissue lysates (35ug/lane).TESC (arrow) was detected using the purified Pab.
Application
TESC Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TESC Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
TESC Antibody (C-term) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
