Application
TFRC Antibody (Cat. #AM2075b) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the TFRC antibody detected the TFRC protein (arrow).| Product Name | TFRC Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 514CT23.4.1 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100~250 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | TFRC Transferrin receptor protein 1 T9 p90 CD_antigen=CD71 Transferrin receptor protein 1 serum form |
|---|---|
| Molecular Weight(MW) | 84871 Da |
| Function | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site |
| Tissue Specificity | Purified His-tagged TFRC protein(Fragment) was used to produced this monoclonal antibody. |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV |
| Entrez Gene | 7037 |
|---|---|
| Nucleotide Accession | NP_001121620.1 |
Application
TFRC Antibody (Cat. #AM2075b) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the TFRC antibody detected the TFRC protein (arrow).| Application Notes | WB:1:100~250 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
