TIMP1 CLGI TIMP Metalloproteinase inhibitor 1 Fibroblast collagenase inhibitor
Molecular Weight(MW)
23171 Da
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14
Tissue Specificity
A synthetic peptide corresponding to residues in the C-terminal region of human TIMP-1 was used as immunogen.