Application
TLR3 Antibody (Cat. #AM1944b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the TLR3 antibody detected the TLR3 protein (arrow).| Product Name | TLR3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 303CT19.9.2 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | TLR3 Toll-like receptor 3 CD_antigen=CD283 Flags: Precursor |
|---|---|
| Molecular Weight(MW) | 103829 Da |
| Function | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response |
| Tissue Specificity | Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane |
| Entrez Gene | 7098 |
|---|---|
| Nucleotide Accession | NP_003256.1 |
Application
TLR3 Antibody (Cat. #AM1944b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the TLR3 antibody detected the TLR3 protein (arrow).| Application Notes | WB:1:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
