Application
A. Western blot analysis on human brain tissue lysate using anti-TNFR1 Rabbit Monoclonal (Cat. #AJ1778a), dilution 1:500.| Product Name | TNFR1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TNFRSF1A, TNFAR, TNFR1, Tumor necrosis factor-binding protein 1, p60;p55 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP1651AY |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | TNFAR TNFR1 |
|---|---|
| Alternative Names | TNFRSF1A TNFAR TNFR1 Tumor necrosis factor-binding protein 1 p60 p55 |
| Molecular Weight(MW) | 50495 Da |
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase |
| Tissue Specificity | A synthetic peptide corresponding to the extracellular portion of human TNFR1 was used as immunogen. |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is produced through proteolytic processing |
| Entrez Gene | 7132 |
|---|
Application
A. Western blot analysis on human brain tissue lysate using anti-TNFR1 Rabbit Monoclonal (Cat. #AJ1778a), dilution 1:500.| Application Notes | WB:1:500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
