Application
TRPV1 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TRPV1 antibody detected the TRPV1 protein (arrow).Application
TRPV1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRPV1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | TRPV1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRPV1; VR1; Transient receptor potential cation channel subfamily V member 1; Capsaicin receptor; Osm-9-like TRP channel 1; Vanilloid receptor 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | VR1 |
|---|---|
| Alternative Names | TRPV1 VR1 Transient receptor potential cation channel subfamily V member 1 Capsaicin receptor Osm-9-like TRP channel 1 Vanilloid receptor 1 |
| Molecular Weight(MW) | 94956 Da |
| Function | Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity) |
| Tissue Specificity | Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level) |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Cell projection, dendritic spine membrane; Multi-pass membrane protein (By similarity) |
| Entrez Gene | 7442 |
|---|---|
| Nucleotide Accession | NP_542437.2 NP_542435.2 NP_061197.4 |
Application
TRPV1 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TRPV1 antibody detected the TRPV1 protein (arrow).
Application
TRPV1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRPV1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
