Application
TSC1 Antibody (Cat. #AM1977b) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the TSC1 antibody detected the TSC1 protein (arrow).| Product Name | TSC1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TSC1; KIAA0243; TSC; Hamartin; Tuberous sclerosis 1 protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b |
| Clone Number | 357CT4.4.2 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100~250 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0243 TSC |
|---|---|
| Alternative Names | TSC1 KIAA0243 TSC Hamartin Tuberous sclerosis 1 protein |
| Molecular Weight(MW) | 129767 Da |
| Function | In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling |
| Tissue Specificity | Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells |
| Cellular Localization | Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes |
| Entrez Gene | 7248 |
|---|---|
| Nucleotide Accession | NP_000359.1 NP_001155898.1 |
Application
TSC1 Antibody (Cat. #AM1977b) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the TSC1 antibody detected the TSC1 protein (arrow).| Application Notes | WB:1:100~250 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
