Application
WWOX Antibody (C-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the WWOX antibody detected the WWOX protein (arrow).| Product Name | WWOX Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | WWOX; FOR; WOX1; WW domain-containing oxidoreductase; Fragile site FRA16D oxidoreductase |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FOR WOX1 |
|---|---|
| Alternative Names | WWOX FOR WOX1 WW domain-containing oxidoreductase Fragile site FRA16D oxidoreductase |
| Molecular Weight(MW) | 46677 Da |
| Function | Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm |
| Tissue Specificity | Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines Isoform 5 and isoform 6 may only be expressed in tumor cell lines |
| Cellular Localization | Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus. Note=Partially localizes to the mitochondria Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1. Isoform 5 and isoform 6 may localize in the nucleus |
| Entrez Gene | 51741 |
|---|---|
| Nucleotide Accession | NP_057457.1 NP_570607.1 |
Application
WWOX Antibody (C-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the WWOX antibody detected the WWOX protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
