| Gene Symbol |
WWOX
|
| Gene Synonyms |
FOR WOX1 DEE28 EIEE28 FRA16D SCAR12 HHCMA56 PRO0128 SDR41C1 D16S432E |
| Gene Full Name |
WW domain containing oxidoreductase |
| Gene Summary |
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| Molecular Weight(MW) |
47 kDa |
| Cellular Localization |
Cytoplasm, Golgi apparatus, Lysosome, Mitochondrion, Nucleus. |