Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes
Tissue Specificity
This ALOX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 617~647 amino acids from the C-terminal region of human ALOX5.
Cellular Localization
Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association
Western blot analysis of anti-ALOX5 Antibody (C-term) in Jurkat cell line lysates (35ug/lane). ALOX5(arrow) was detected using the purified Pab.
Application Notes
WB:1:50~100
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.