Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation
Tissue Specificity
Expressed in all tissues examined. Up- regulated in diabetic heart
Cellular Localization
Membrane; Single-pass membrane protein (Potential). Secreted