Application
Western blot analysis of anti-ATXN1 Antibody (S776) in CEM cell line lysates (35ug/lane). ATXN1 (arrow) was detected using the purified Pab.Application
Confocal immunofluorescent analysis of ATXN1 Antibody (S776)(Cat#AP2808a) with hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).| Product Name | ATXN1 Antibody (S776) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIF |
| WB:1:100~500 IF |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ATX1, SCA1 |
|---|---|
| Alternative Names | ATXN1 ATX1 SCA1 Ataxin-1 Spinocerebellar ataxia type 1 protein |
| Molecular Weight(MW) | 86923 Da |
| Function | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function |
| Tissue Specificity | Widely expressed throughout the body. |
| Cellular Localization | Cytoplasm (By similarity). Nucleus. Note=Colocalizes with USP7 in the nucleus |
| Entrez Gene | 6310 |
|---|
Application
Western blot analysis of anti-ATXN1 Antibody (S776) in CEM cell line lysates (35ug/lane). ATXN1 (arrow) was detected using the purified Pab.
Application
Confocal immunofluorescent analysis of ATXN1 Antibody (S776)(Cat#AP2808a) with hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).| Application Notes | WB:1:100~500 IF |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
