Application
Figure 1: Immunohistochemical analysis of paraffin-embedded human normal myocardium, showing cytoplasmic localization using anti-BNP1 antibody with DAB staining.| Product Name | BNP Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BNP; NPPB |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 8D5B4C11 |
| Host Species | Mouse |
| Tested Applications | IHC |
| IHC:1:200 - 1000. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | BNP NPPB |
|---|---|
| Molecular Weight(MW) | 14726 Da |
| Function | Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 |
| Tissue Specificity | Brain and also in atria, but at much lower levels than ANP |
| Cellular Localization | Secreted. |
| Entrez Gene | 4879 |
|---|---|
| Nucleotide Accession | NP_002512.1 |
Application
Figure 1: Immunohistochemical analysis of paraffin-embedded human normal myocardium, showing cytoplasmic localization using anti-BNP1 antibody with DAB staining.| Application Notes | IHC:1:200 - 1000. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Synthetic peptide corresponding to aa (Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser) of human BNP, conjugated to KLH. |
