Application
Figure 1: Western blot analysis using BMX mAb against BMX-hIgGFc transfected HEK293 cell lysate.| Product Name | BMX Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ETK; PSCTK2; PSCTK3; BMX |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 1C6 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:500 - 2000. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | ETK PSCTK2 PSCTK3 BMX |
|---|---|
| Molecular Weight(MW) | 78011 Da |
| Function | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation Also involved in interleukin-6 (IL6) induced differentiation Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells |
| Tissue Specificity | Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines |
| Cellular Localization | Cytoplasm. Note=Localizes to the edges of spreading cells when complexed with BCAR1 |
| Entrez Gene | 660 |
|---|---|
| Nucleotide Accession | NP_975010.1 |
Application
Figure 1: Western blot analysis using BMX mAb against BMX-hIgGFc transfected HEK293 cell lysate.| Application Notes | WB:1:500 - 2000. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified recombinant fragment of human BMX expressed in E. Coli. |
