Application
Western blot analysis of CASP1 Antibody (N-term) in MDA-MB468 cell line lysates (35ug/lane). CASP1 (arrow) was detected using the purified Pab.Application
CASP1 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CASP1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | CASP1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CASP1; IL1BC; IL1BCE; Caspase-1; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45; Caspase-1 subunit p20; Caspase-1 subunit p10 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:50~100 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | IL1BC IL1BCE |
|---|---|
| Alternative Names | CASP1 IL1BC IL1BCE Caspase-1 Interleukin-1 beta convertase Interleukin-1 beta-converting enzyme p45 Caspase-1 subunit p20 Caspase-1 subunit p10 |
| Molecular Weight(MW) | 45159 Da |
| Function | Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis |
| Tissue Specificity | Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain |
| Cellular Localization | Cytoplasm. |
| Entrez Gene | 834 |
|---|
Application
Western blot analysis of CASP1 Antibody (N-term) in MDA-MB468 cell line lysates (35ug/lane). CASP1 (arrow) was detected using the purified Pab.
Application
CASP1 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CASP1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:50~100 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
