Application
A. Western blot analysis on TF-1 lysate using anti-ITAM RabMAb (Cat. #AJ1149a), dilution 1:20,000Application
B. Immunohistochemical analysis of paraffin-embedded human spleen using anti-ITAM RabMAb (Cat. #AJ1149a).| Product Name | CD11b/ITAM Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP1345Y |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CD11B, CR3A |
|---|---|
| Alternative Names | ITGAM CD11B CR3A Integrin alpha-M Cell surface glycoprotein MAC-1 subunit alpha CR-3 alpha chain Leukocyte adhesion receptor MO1 Neutrophil adherence receptor CD11 antigen-like family member B |
| Molecular Weight(MW) | 127179 Da |
| Function | Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain |
| Tissue Specificity | Predominantly expressed in monocytes and granulocytes |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Entrez Gene | 3684 |
|---|
Application
A. Western blot analysis on TF-1 lysate using anti-ITAM RabMAb (Cat. #AJ1149a), dilution 1:20,000
Application
B. Immunohistochemical analysis of paraffin-embedded human spleen using anti-ITAM RabMAb (Cat. #AJ1149a).| Application Notes | WB:1:500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
