Application
CIB1 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the CIB1 antibody detected the CIB1 protein (arrow).| Product Name | CIB1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CIB1; CIB; KIP; PRKDCIP; Calcium and integrin-binding protein 1; Calcium- and integrin-binding protein; Calmyrin; DNA-PKcs-interacting protein; Kinase-interacting protein; SNK-interacting protein 2-28 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CIB KIP PRKDCIP |
|---|---|
| Alternative Names | CIB1 CIB KIP PRKDCIP Calcium and integrin-binding protein 1 Calcium- and integrin-binding protein Calmyrin DNA-PKcs-interacting protein Kinase-interacting protein SNK-interacting protein 2-28 |
| Molecular Weight(MW) | 21703 Da |
| Function | May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes) Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation |
| Tissue Specificity | Ubiquitous. |
| Cellular Localization | Membrane; Lipid-anchor. Cytoplasm. Nucleus. Cell projection, filopodium. Apical cell membrane. Note=Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells |
| Entrez Gene | 10519 |
|---|---|
| Nucleotide Accession | NP_006375.2 |
Application
CIB1 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the CIB1 antibody detected the CIB1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
