Application
COBRA1 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the COBRA1 antibody detected the COBRA1 protein (arrow).| Product Name | COBRA1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | COBRA1; KIAA1182; NELFB; Negative elongation factor B; Cofactor of BRCA1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | COBRA1 KIAA1182 |
|---|---|
| Alternative Names | COBRA1 KIAA1182 NELFB Negative elongation factor B Cofactor of BRCA1 |
| Molecular Weight(MW) | 65697 Da |
| Function | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding |
| Tissue Specificity | Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas |
| Cellular Localization | Nucleus. |
| Entrez Gene | 25920 |
|---|---|
| Nucleotide Accession | NP_056271.2 |
Application
COBRA1 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the COBRA1 antibody detected the COBRA1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
