Application
The anti-CRK7 Pab is used in Western blot to detect CRK7 in mouse liver tissue lysate.| Product Name | CrkRS (CRK7) Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CDK12; CRK7; CRKRS; KIAA0904; Cyclin-dependent kinase 12; Cdc2-related kinase, arginine/serine-rich; Cell division cycle 2-related protein kinase 7; Cell division protein kinase 12 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CRK7 CRKRS KIAA0904 |
|---|---|
| Alternative Names | CDK12 CRK7 CRKRS KIAA0904 Cyclin-dependent kinase 12 Cdc2-related kinase arginine/serine-rich Cell division cycle 2-related protein kinase 7 Cell division protein kinase 12 |
| Molecular Weight(MW) | 164155 Da |
| Function | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors |
| Tissue Specificity | Ubiquitously expressed. |
| Cellular Localization | Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase |
| Entrez Gene | 51755 |
|---|
Application
The anti-CRK7 Pab is used in Western blot to detect CRK7 in mouse liver tissue lysate.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
