Application
CYP1A2 Antibody (Cat. #AM2066b) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the CYP1A2 antibody detected the CYP1A2 protein (arrow).| Product Name | CYP1A2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CYP1A2; Cytochrome P450 1A2; CYPIA2; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG3 |
| Clone Number | 499CT13.2.2 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100~250 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | CYP1A2 Cytochrome P450 1A2 CYPIA2 Cytochrome P(3)450 Cytochrome P450 4 Cytochrome P450-P3 |
|---|---|
| Molecular Weight(MW) | 58294 Da |
| Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin |
| Tissue Specificity | Liver. |
| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein |
| Entrez Gene | 1544 |
|---|---|
| Nucleotide Accession | NP_000752.2 |
Application
CYP1A2 Antibody (Cat. #AM2066b) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the CYP1A2 antibody detected the CYP1A2 protein (arrow).| Application Notes | WB:1:100~250 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
