Application
Figure 1: Western blot analysis using anti-DDR2 mAb against truncated DDR2 recombinant protein.Application
Figure 2: Immunohistochemical analysis of paraffin-embedded human skeletal musle tissues using anti-DDR2 mAb.Application
Figure 3: Confocal immunofluorescence analysis of A549 cells using anti-DDR2 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.| Product Name | DDR2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TKT; MIG20a; NTRKR3; TYRO10 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | 3B11E4 |
| Host Species | Mouse |
| Tested Applications | WBIHCIF |
| WB:1:500 - 2000. IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NTRKR3 TKT TYRO10 |
|---|---|
| Alternative Names | TKT MIG20a NTRKR3 TYRO10 |
| Molecular Weight(MW) | 96736 Da |
| Function | Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing |
| Tissue Specificity | Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Entrez Gene | 4921 |
|---|---|
| Nucleotide Accession | NP_006173.2 |
Application
Figure 1: Western blot analysis using anti-DDR2 mAb against truncated DDR2 recombinant protein.
Application
Figure 2: Immunohistochemical analysis of paraffin-embedded human skeletal musle tissues using anti-DDR2 mAb.
Application
Figure 3: Confocal immunofluorescence analysis of A549 cells using anti-DDR2 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.| Application Notes | WB:1:500 - 2000. IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified recombinant fragment of human DDR2 expressed in E. Coli. |
