Application
DERL3 Antibody (C-term) western blot analysis in mouse liver tissue lysates (15ug/lane).This demonstrates the DERL3 antibody detected DERL3 protein (arrow).Application
DERL3 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DERL3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.Application
DERL3 Antibody (C-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | DERL3 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DERL3; C22orf14; DER3; LLN2; Derlin-3; Degradation in endoplasmic reticulum protein 3; Der1-like protein 3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHCFC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | C22orf14 DER3 LLN2 |
|---|---|
| Alternative Names | DERL3 C22orf14 DER3 LLN2 Derlin-3 Degradation in endoplasmic reticulum protein 3 Der1-like protein 3 |
| Molecular Weight(MW) | 26679 Da |
| Function | Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate |
| Tissue Specificity | Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Entrez Gene | 91319 |
|---|---|
| Nucleotide Accession | NP_001129223.1 NP_940842.2 |
Application
DERL3 Antibody (C-term) western blot analysis in mouse liver tissue lysates (15ug/lane).This demonstrates the DERL3 antibody detected DERL3 protein (arrow).
Application
DERL3 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DERL3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
DERL3 Antibody (C-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
