Application
Figure 1: Western blot analysis using anti-DKK1 monoclonal antibody against HEK293 (1) and DKK1-hIgGFc transfected HEK293 cell lysate(2).| Product Name | DKK1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SK; DKK-1; |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b |
| Clone Number | 2H2 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:500 - 2000. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | SK DKK-1 |
|---|---|
| Molecular Weight(MW) | 28672 Da |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease |
| Tissue Specificity | Placenta. |
| Cellular Localization | Secreted. |
| Entrez Gene | 22943 |
|---|---|
| Nucleotide Accession | NP_036374.1 |
Application
Figure 1: Western blot analysis using anti-DKK1 monoclonal antibody against HEK293 (1) and DKK1-hIgGFc transfected HEK293 cell lysate(2).| Application Notes | WB:1:500 - 2000. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified recombinant fragment of DKK1 expressed in E. Coli. |
