Application
Figure 1: Western blot analysis using anti-EhpB6 monoclonal antiobdy against truncated EhpB6 recombinant protein(1).Application
Figure 2: Immunohistochemical analysis of paraffin-embedded human lymph node(left) and brain(right), showing cytoplasmic localization with DAB staining using anti-EhpB6 antibody.| Product Name | EhpB6 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 2A6B9 |
| Host Species | Mouse |
| Tested Applications | WBIHC |
| WB:1:500 - 2000. IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | HEP EPHB6 |
|---|---|
| Molecular Weight(MW) | 110700 Da |
| Function | Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 |
| Tissue Specificity | Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Entrez Gene | 2051 |
|---|---|
| Nucleotide Accession | NP_004436.2 |
Application
Figure 1: Western blot analysis using anti-EhpB6 monoclonal antiobdy against truncated EhpB6 recombinant protein(1).
Application
Figure 2: Immunohistochemical analysis of paraffin-embedded human lymph node(left) and brain(right), showing cytoplasmic localization with DAB staining using anti-EhpB6 antibody.| Application Notes | WB:1:500 - 2000. IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified recombinant fragment of EphB6(aa601-750) expressed in E. Coli. |
