Application
Western blot analysis of FKBP12 (arrow) using rabbit polyclonal FKBP12 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FKBP12 gene (Lane 2) (Origene Technologies).| Product Name | FKBP12 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FKBP1A; FKBP1; FKBP12; Peptidyl-prolyl cis-trans isomerase FKBP1A; 12 kDa FK506-binding protein; Calstabin-1; FK506-binding protein 1A; Immunophilin FKBP12; Rotamase |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FKBP1 FKBP12 |
|---|---|
| Alternative Names | FKBP1A FKBP1 FKBP12 Peptidyl-prolyl cis-trans isomerase FKBP1A 12 kDa FK506-binding protein Calstabin-1 FK506-binding protein 1A Immunophilin FKBP12 Rotamase |
| Molecular Weight(MW) | 11951 Da |
| Function | Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides |
| Tissue Specificity | This FKBP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51~81 amino acids from the Center region of human FKBP12. |
| Cellular Localization | Cytoplasm. |
| Entrez Gene | 2280 |
|---|
Application
Western blot analysis of FKBP12 (arrow) using rabbit polyclonal FKBP12 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FKBP12 gene (Lane 2) (Origene Technologies).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
