Application
FMR1 Antibody (Cat. #AM2076b) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the FMR1 antibody detected the FMR1 protein (arrow).| Product Name | FMR1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FMR1; Fragile X mental retardation protein 1 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 508CT17.2.2 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100~250 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | FMR1 Fragile X mental retardation protein 1 |
|---|---|
| Molecular Weight(MW) | 71174 Da |
| Function | Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C) |
| Tissue Specificity | Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells |
| Cellular Localization | Cytoplasm. Nucleus, nucleolus. |
| Entrez Gene | 2332 |
|---|---|
| Nucleotide Accession | NP_001172004.1 |
Application
FMR1 Antibody (Cat. #AM2076b) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the FMR1 antibody detected the FMR1 protein (arrow).| Application Notes | WB:1:100~250 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
