Application
A. Western blot analysis on human brain lysate using anti-GluR3 RabMAb (Cat. #AJ1324a), dilution 1:5,000Application
B. Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-GluR3 RabMAb (Cat. #AJ1324a).| Product Name | GluR3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GRIA3, GLUR3, GLURC, Glutamate receptor 3, GluR-K3;Glutamate receptor ionotropic, AMPA 3;AMPA-selective glutamate receptor 3 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP813Y |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:1000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | GLUR3 GLURC |
|---|---|
| Alternative Names | GRIA3 GLUR3 GLURC Glutamate receptor 3 GluR-K3 Glutamate receptor ionotropic AMPA 3 AMPA-selective glutamate receptor 3 |
| Molecular Weight(MW) | 101157 Da |
| Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate |
| Tissue Specificity | A synthetic peptide corresponding to residues in the human Glutamate receptor type 3 was used as an immunogen. |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression (By similarity) |
| Entrez Gene | 2892 |
|---|
Application
A. Western blot analysis on human brain lysate using anti-GluR3 RabMAb (Cat. #AJ1324a), dilution 1:5,000
Application
B. Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-GluR3 RabMAb (Cat. #AJ1324a).| Application Notes | WB:1:1000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
