Application
HAND1 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the HAND1 antibody detected the HAND1 protein (arrow).| Product Name | HAND1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HAND1; BHLHA27; EHAND; Heart- and neural crest derivatives-expressed protein 1; Class A basic helix-loop-helix protein 27; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BHLHA27 EHAND |
|---|---|
| Alternative Names | HAND1 BHLHA27 EHAND Heart- and neural crest derivatives-expressed protein 1 Class A basic helix-loop-helix protein 27 Extraembryonic tissues heart autonomic nervous system and neural crest derivatives-expressed protein 1 |
| Molecular Weight(MW) | 23627 Da |
| Function | Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box) (By similarity) |
| Tissue Specificity | Heart. |
| Cellular Localization | Nucleus, nucleoplasm (By similarity). Nucleus, nucleolus (By similarity). Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity) |
| Entrez Gene | 9421 |
|---|---|
| Nucleotide Accession | NP_004812.1 |
Application
HAND1 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the HAND1 antibody detected the HAND1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
