Application
HDAC1 Antibody (Cat. #AM2204b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the HDAC1 antibody detected the HDAC1 protein (arrow).| Product Name | HDAC1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HDAC1;RPD3L1; Histone deacetylase 1 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 1061CT1.3.1 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:1000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | RPD3L1 |
|---|---|
| Alternative Names | HDAC1 RPD3L1 Histone deacetylase 1 |
| Molecular Weight(MW) | 55103 Da |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development |
| Tissue Specificity | Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain |
| Cellular Localization | Nucleus. |
| Entrez Gene | 3065 |
|---|
Application
HDAC1 Antibody (Cat. #AM2204b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the HDAC1 antibody detected the HDAC1 protein (arrow).| Application Notes | WB:1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
