ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation In case of rhinovirus infection acts as a cellular receptor for the virus
Tissue Specificity
Purified recombinant fragment of human ICAM1(28-480aa) expressed in E. Coli.