Application
LRDD Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the LRDD antibody detected the LRDD protein (arrow).Application
LRDD Antibody (C-term) (AP13884b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LRDD Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | LRDD Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | LRDD |
|---|---|
| Alternative Names | PIDD LRDD p53-induced protein with a death domain Leucine-rich repeat and death domain-containing protein |
| Molecular Weight(MW) | 99712 Da |
| Function | Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways |
| Tissue Specificity | Ubiquitous. |
| Cellular Localization | Cytoplasm. Nucleus. |
| Entrez Gene | 55367 |
|---|---|
| Nucleotide Accession | NP_665894.2 NP_665893.2 |
Application
LRDD Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the LRDD antibody detected the LRDD protein (arrow).
Application
LRDD Antibody (C-term) (AP13884b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LRDD Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
