Application
Western blot analysis on (A) PMBC, (B) A549, (C) mouse brain, (D) mouse heart, (E) mouse kidney, (F) mouse spleen, (G) rat brain, (H) rat heart, (I) rat kidney and (J) rat spleen lysates using anti-LRP1 RabMAb (Cat. #AJ1448a).Application
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-LRP1 RabMAb.Application
Immunofluorescent staining of HEPG2 cells using anti-LRP1 RabMAb (Cat. #AJ1448a).| Product Name | LRP1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EPR3724 |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:20000~50000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | A2MR, APR |
|---|---|
| Alternative Names | LRP1 A2MR APR Low-density lipoprotein receptor-related protein 1 intracellular domain Apolipoprotein E receptor |
| Molecular Weight(MW) | 504606 Da |
| Function | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission |
| Tissue Specificity | Most abundant in liver, brain and lung. |
| Cellular Localization | Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus |
| Entrez Gene | 4035 |
|---|
Application
Western blot analysis on (A) PMBC, (B) A549, (C) mouse brain, (D) mouse heart, (E) mouse kidney, (F) mouse spleen, (G) rat brain, (H) rat heart, (I) rat kidney and (J) rat spleen lysates using anti-LRP1 RabMAb (Cat. #AJ1448a).
Application
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-LRP1 RabMAb.
Application
Immunofluorescent staining of HEPG2 cells using anti-LRP1 RabMAb (Cat. #AJ1448a).| Application Notes | WB:1:20000~50000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
