| Product Name | ACTH antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [57 (BGN/1388/66)] to ACTHThis gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endo |
| Immunogen | Synthetic peptide corresponding to the amino acids 1 - 24 of the human ACTH conjugated to Keyhole Limpet Haemocyanin. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 57 (BGN/1388/66) |
| Host Species | Mouse |
| Tested Applications | ELISAIHC-P |
| Immunohistology - Paraffin: 1/100 - 1/200 Optimal dilution / concentration should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | POC LPH proopiomelanocortin POMC NPP MSH CLIP |
|---|---|
| Target | ACTH |
| Tissue Specificity | This antibody recognizes 1-24 ACTH (Synacthen) and does not recognize 17-39 ACTH (CLIP). It does cross-reacts with rat N-terminal ACTH. |
| Application Notes | Immunohistology - Paraffin: 1/100 - 1/200 Optimal dilution / concentration should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | Phosphate buffered saline containing 0.09% Sodium Azide (NaN3) |
