Rabbit Polyclonal antibody to AKR1C3This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Immunogen
Recombinant protein of human AKR1C3
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHCIHC-PWB
WB: 1:500 - 1:2000, IHC: 1:50 - 1:200:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
hluPGFS HAKRe HA1753 PGFS HAKRB DD3 HSD17B5 DDX aldo-keto reductase family 1 member C3
Target
AKR1C3
Application
Application
Western blot analysis of extracts of various cell line, using AKR1C3 antibody.
Application
Immunohistochemistry of paraffin-embedded rat heart using AKR1C3 antibody at dilution of 1:100 (400x lens).