| Product Name | Alpha fetoprotein / AFP antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [4A3] to alpha FetoproteinThis is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. |
| Immunogen | Full length, purified human alpha fetoprotein protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | 4A3 |
| Host Species | Mouse |
| Tested Applications | ELISA |
| ELISA: Use at an assay dependent dilution. Can be used in an ELISA pair (GTX10071 as capture antibody and GTX10072 as detection antibody). Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | HPAFP 174 FETA 104150 alpha Fetoprotein AFP P02771 |
|---|---|
| Target | alpha Fetoprotein |
| Tissue Specificity | and react with different determinants of human alpha-fetoprotein. Does not react with human albumin. |
| Cellular Localization | Secreted |
| Application Notes | ELISA: Use at an assay dependent dilution. Can be used in an ELISA pair (GTX10071 as capture antibody and GTX10072 as detection antibody). Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | Phosphate-buffered saline, pH 7.4, containing 0.1% sodium azide |
