Mouse monoclonal [KAB4] to ALX4Alx4, a novel paired-like-homeodomain protein, is a transcriptional activation factor whose expression is restricted to sites of epithelial mesenchymal interactions. A negative feedback loop exists between Alx4 and Shh (Sonic hedgehog) during limb outgrowth. The anterior localization of Alx4 in the limb bud is a key factor in determining the correct anteriorposterior axis of the vertebrate limb. Alx4 is expressed on a variety of tissues including: osteoblast precursors, dermal papilla of hair and whisker follicles, dental papilla of teeth, and mesenchymal cells.
Immunogen
Recombinant full length protein (Human).
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
KAB4
Host Species
Mouse
Tested Applications
WB
WB: Use at a concentration of 1 - 5 μg/ml. Detects bands of approximately 41 and 43 kDa. Optimal dilutions/concentrations should be determined by the end user.
Species Reactivity
Human
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
WB: Use at a concentration of 1 - 5 μg/ml. Detects bands of approximately 41 and 43 kDa. Optimal dilutions/concentrations should be determined by the end user.
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.