Mouse Monoclonal antibody [8A7-F8-G12] to Annexin VIAnnexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described.
Immunogen
Purified recombinant human ANXA6 protein fragments expressed in E.coli.
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
8A7-F8-G12
Host Species
Mouse
Tested Applications
WB
Species Reactivity
Human
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
ANXA6 , ANX6 , annexin A6 , CBP68
Target
Annexin VI
Molecular Weight(MW)
76kDa (note)
Cellular Localization
Cytoplasm,Melanosome
Application
Application
WB analysis of T47D, MB4, CEM, MOLT-4 and Jurkat lysates using Annexin VI antibody at a dilution of 1:1,000.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide, 50% glycerol, 0.1%BSA