Application
Immunohistochemistry of ARC in human heart tissue (A) with ARC antibody at 5 μg/ml.Application
Western blot analysis of ARC in HeLa (H), KB (K), and A549 (A) whole cell lysates with ARC antibody at 1ug/ml.Application
Immunohistochemistry of ARC in human skeletal muscle (B) with ARC antibody at 5 μg/ml.| Product Name | ARC antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to ARCApoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, Caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and ~8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1). |
| Immunogen | Synthetic peptide, corresponding to amino acids 191-208 of Human ARC. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| This polyclonal antibody can be used for detection of ARCby Western blot at 1:1000 dilution. A band at 25 kD can be seen. | |
| Species Reactivity | Human |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | NOP30, ARC, NOP, 8996, O60936, 605235, NOL3, MYC |
|---|---|
| Target | ARC |
Application
Immunohistochemistry of ARC in human heart tissue (A) with ARC antibody at 5 μg/ml.
Application
Western blot analysis of ARC in HeLa (H), KB (K), and A549 (A) whole cell lysates with ARC antibody at 1ug/ml.
Application
Immunohistochemistry of ARC in human skeletal muscle (B) with ARC antibody at 5 μg/ml.| Positive Control | HeLa whole cell lysate |
|---|---|
| Application Notes | This polyclonal antibody can be used for detection of ARCby Western blot at 1:1000 dilution. A band at 25 kD can be seen. |
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.02% Sodium Azide; Constituents: PBS |
