| Product Name | BACE2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to BACE2Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor(APP) at b- and g-sites by proteases. The long-sought-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down Region Aspartic Protease), and memapsin 1 (4-9). BACE2 also cleaves APP at b-site and at a different site within Ab (8). BACE2 locates on chromosome 21q22.3, the so-called Down critical region, suggesting thatBACE2 and Ab may also contribute to the pathogenesis of Down syndrome (6,7). |
| Immunogen | Synthetic peptide, corresponding to amino acids 496-511 of Human BACE 2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western blot: 1 : 5 0 0 - 1 : 1 , 0 0 0: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 0.5mg/ml |
| Gene Synonyms | ALP56 DRAP 605668 Q9Y5Z0 CEAP1 BAE2 CDA13 BACE2 AEPLC ASP21 ASP1 25825 |
|---|---|
| Target | BACE2 |
| Positive Control | Human heart tissue lysate. |
|---|---|
| Application Notes | Western blot: 1 : 5 0 0 - 1 : 1 , 0 0 0: |
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide |
