Application
Application| Product Name | BAFF antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [Buffy XI] to BAFFMembers in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL1 (for TNF- and ApoL- related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NFkB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell stimulator since it induced B cell proliferation and immunoglobulin secretion. Two receptors for BAFF were recently identified and designated TACI and BCMA. BAFF and its receptors are involved in the development of systemic lupus erythaematosus and other B cell associated autoimmune diseases. Like TNFa and TRAIL,THANK was shown to activate NF-kB and c-jun N terminal kinase (JNK) and to induce apoptosis. |
| Immunogen | Extracellular domain of Human BAFF, corresponding to amino acids 137 - 285. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | Buffy XI |
| Host Species | Mouse |
| Tested Applications | WB |
| WB: Use at a concentration of 1 μg/ml. Predicted molecular weight: 34 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | 10673 603969 Q9Y275 TNFSF20 delta BAFF TALL1 BAFF TALL-1 ZTNF4 TNFSF13B THANK BLYS TALL 1 |
|---|---|
| Target | BAFF |
| Cellular Localization | Type II membrane protein. Also exists as an extracellular soluble form. |
Application
Application| Application Notes | WB: Use at a concentration of 1 μg/ml. Predicted molecular weight: 34 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.02% Sodium Azide; Constituents: PBS |
