Rabbit polyclonal antibody to Bcl-wThis gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
Immunogen
Recombinant protein of human BCL2L2
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
WB: 1:500 - 1:2000. IHC: 1:50 - 1:200.:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
BCL2-L-2 BCL2-like 2 PPP1R51 BCL-W BCL2L2 BCLW
Target
Bcl-w
Molecular Weight(MW)
21 kDa (note)
Application
Application
WB analysis of mouse eye lysate using Bcl-w antibody.
Application
IHC-P analysis of human kidney carcinoma tissue using Bcl-w antibody.
Application Notes
WB: 1:500 - 1:2000. IHC: 1:50 - 1:200.:
Additional Information
Form
Liquid
Storage Instructions
Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles.