Application
ELISA analysis of control antigen and antigen using BRCA1 antibody [6C6D2].Application
WB analysis of human BRCA1 recombinant protein using BRCA1 antibody [6C6D2].Application
WB analysis of lysates from (1) untransfected and (2) BRCA1 (a.a. 229-335)-hIgGFc transfected HEK293 cells using BRCA1 antibody [6C6D2].Application
IHC-P analysis of esophagus cancer tissues using BRCA1 antibody [6C6D2].Application
IHC-P analysis of esophagus tissues using BRCA1 antibody [6C6D2].| Product Name | BRCA1 antibody [6C6D2] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal Antibody [6C6D2] to BRCA1This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the f |
| Immunogen | The immunogen corresponding to a region within amino acids 229 and 335 of human BRCA1 expressed in E. Coli. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 6C6D2 |
| Host Species | Mouse |
| Tested Applications | ELISA,IHC,IHC-P,WB |
| ELISA: 1/10000. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Gene Synonyms | IRIS , PNCA4 , BRCC1 , PPP1R53 , BROVCA1 , PSCP , BRCAI , RNF53 |
|---|---|
| Target | BRCA1 |
| Molecular Weight(MW) | 207.7 kDa (note) |
Application
ELISA analysis of control antigen and antigen using BRCA1 antibody [6C6D2].
Application
WB analysis of human BRCA1 recombinant protein using BRCA1 antibody [6C6D2].
Application
WB analysis of lysates from (1) untransfected and (2) BRCA1 (a.a. 229-335)-hIgGFc transfected HEK293 cells using BRCA1 antibody [6C6D2].
Application
IHC-P analysis of esophagus cancer tissues using BRCA1 antibody [6C6D2].
Application
IHC-P analysis of esophagus tissues using BRCA1 antibody [6C6D2].| Application Notes | ELISA: 1/10000. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | 4°C; -20°C for long term storage |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer. |
