Mouse monoclonal antibody [5C10, ADD] to Calcium Sensing ReceptorThe protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]
Immunogen
Synthetic peptide corresponding to residues (214) A D D D Y G R P G I E K F RE E A E E R D I (235) of human calcium sensing receptor.
Key Feature
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
5C10, ADD
Host Species
Mouse
Tested Applications
ELISAFACSICC/IFIHCIHC-FIPWB
ICC/IF: 1:50 - 1:1000:
Species Reactivity
HumanMousePigRatBovine
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Protein A
Target Information
Gene Synonyms
PCAR1 GPRC2A FHH CAR EIG8 FIH NSHPT HHC1 CASR calcium-sensing receptor HHC
Target
Calcium Sensing Receptor
Application
Application
Western blot analysis of calcium sensing receptor in HEK7-2 cell extract.
Application
Immunofluorescent analysis of bovine corneal epithelium (CE) limbus tissue using Calcium Sensing Receptor antibody [5C10, ADD].
Application Notes
ICC/IF: 1:50 - 1:1000:
Additional Information
Form
Liquid
Storage Instructions
-20° C, Avoid Freeze/Thaw Cycles
Storage Buffer
PBS containing 0.05 % sodium azide and 1 mg/ml BSA