| Product Name | Cardiac Troponin I antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [458] to Cardiac Troponin ITroponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq] |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 458 |
| Host Species | Mouse |
| Tested Applications | ELISAWB |
| Suitable for use in troponin I immunoassay, troponin I immunoaffinity purification and Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Recommended pair for ELISA: clone 560 (GTX38795) for capture and clone 458 (this antibody) for detection.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CMH7 MGC116817 TNNC1 cTnI |
|---|---|
| Target | Cardiac Troponin I |
| Tissue Specificity | Troponin I-Cardiac (169-178 Region) |
| Application Notes | Suitable for use in troponin I immunoassay, troponin I immunoaffinity purification and Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Recommended pair for ELISA: clone 560 (GTX38795) for capture and clone 458 (this antibody) for detection.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt, store at –20°C. Avoid multiple freeze/thaw cycles. |
| Storage Buffer | PBS, pH 7.4 and 0.09% Sodium Azide |
