| Product Name | CD299 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [2U25] to CD299This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a signifi |
| Immunogen | Human recombinant CD299 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 2U25 |
| Host Species | Mouse |
| Tested Applications | FACSNeut |
| FC(1:50-100)|Neutralization of DC-SIGNR bioactivity: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | L-SIGN CLEC4M DC-SIGN2 DCSIGNR LSIGN DC-SIGNR HP10347 CD209L |
|---|---|
| Target | CD299 |
| Tissue Specificity | This antibody was selected for its ability to detect human CD299. |
| Application Notes | FC(1:50-100)|Neutralization of DC-SIGNR bioactivity: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
