| Product Name | CD71 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [7-1] to CD71Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients. |
| Immunogen | Recombinant full length protein (Human) |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 7-1 |
| Host Species | Mouse |
| Tested Applications | ELISA |
| ELISA: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Synonyms | TFR TFR1 7037 190010 Transferrin receptor TFRC CD71 P02786 TRFR |
|---|---|
| Target | CD71 |
| Tissue Specificity | This antibody reacts with human transferrin receptor. |
| Cellular Localization | Type II membrane protein. Secreted (isoform sTfR) |
| Application Notes | ELISA: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | Phosphate-buffered saline, pH 7.4, containing 0.1% sodium azide |
