| Product Name | CD8 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [LT8] to CD8The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. |
| Immunogen | Normal human blood lymphocytes. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | LT8 |
| Host Species | Mouse |
| Tested Applications | Blocking |
| BL: 1/5000. Can be used to enumerate T suppressor/cytotoxic subset in peripheral blood and tissue. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | 186910 P10966 MGC119115 926 LYT3 p32 Ly3 CD8 CD8B 925 MAL Leu2 186730 P01732 CD8B1 CD8A |
|---|---|
| Target | CD8 |
| Tissue Specificity | Reacts with CD8 antigen (MW 32 kDa). LT8 completely cross blocks binding of MAbs Leu 2a and OKT8. Working dilution 1:5000. CD8 present on 23 + 4% of normal peripheral blood lymphocytes and 80% of thymocytes. This antigen is found on T supressor/cytotoxic T cells. |
| Cellular Localization | Cell Membrane |
| Application Notes | BL: 1/5000. Can be used to enumerate T suppressor/cytotoxic subset in peripheral blood and tissue. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | Preservative: 0.1% Sodium Azide. Constituents: PBS. pH 7.4 |
