| Product Name | Clostridium difficile Toxin B antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [5A8-E11] to Clostridium difficile Toxin BClostridium difficile is the causitive organism of pseudomembranous colitis (PMC) or antibiotic associated colitis, a toxin mediated enteric disease that causes serious and sometimes lethal gastrointestinal disease. Antibiotic therapy or chemotherapy agents that possess antibacterial properties alters the colonic flora and allows C. difficile to flourish and release toxins that cause mucosal damage and inflammation. At least two toxins are involved in the disease process: toxin A (or enterotoxin) and toxin B (or cytotoxin). Both are heat labile proteins that activate the release of cytokines from human monocytes. These proinflammatory effects on leukocytes are instrumental in inducing the marked colonic inflammation seen in PMC. |
| Immunogen | Clostridium difficile Toxin B. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 5A8-E11 |
| Host Species | Mouse |
| Tested Applications | ELISAWB |
| Tested in peptide ELISA. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Concentration | 1mg/ml |
| Target | Clostridium difficile Toxin B |
|---|---|
| Cellular Localization | Secreted |
| Light Chain Type | kappa |
| Application Notes | Tested in peptide ELISA. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: None. Constituents: Ascites |
