| Product Name | c-Myc (phospho Thr58) antibody |
|---|---|
| Antibody Type | Tags Antibodies |
| Product description | Rabbit polyclonal antibody to Myc (phospho T58)The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008] |
| Modification | p-Thr58 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| Suggested starting dilutions are as follows. IHC: 1:50-1:100. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | phospho c-Myc Thr58 MRTL BHLHE39 Phospho c-Myc (pT58) Phospho c-Myc (pThr58) c-Myc (Phospho Thr58) phospho c-Myc T58 c-Myc (pThr58) c-Myc (pT58) c-Myc phospho c-Myc Thr58 phospho c-Myc phospho Thr58 phospho T58 c-Myc |
|---|---|
| Target | Myc (phospho T58) |
| Application Notes | Suggested starting dilutions are as follows. IHC: 1:50-1:100. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS (without Mg2+and Ca2+), pH 7.4, 150mM NaCl,0.02% sodium azide and 50% glycerol. |
